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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of poly(β-peptide) with controlled stereochemistry and molecular weight

2016년 9월 1일 15시 17분 40초
POLY.P-92 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 13일 (목요일) 11:00~12:30
저자 및
정록암, 이희승*
KAIST 화학과, Korea
Nature exhibits an abundance of structural materials in the form of protein fibers, which have attained remarkable levels of efficiency and performance through evolutionary selection. Protein fibers such as silk are composed of polyamide, silk is also the strongest natural fiber known.[1] Nylon 3-polymer characteristics are similar to silk and it is known to have bioactivity.[2] But this nylon 3-polymer can be synthesized in the form of chain or cis only.[3] In this study, Efficient synthesis of stereochemistry and molecular weight controlled poly(β-peptide) carried on. We selected a chiral β-amino acid (S,S)-trans-2-aminocyclopentanecarboxylic acid(ACPC), which is an amino acid with a rigid cyclopentane ring. A chiral monomer was synthesized and then a chiral polyamide was formed through polymer reaction in solution. Then, this chiral polyamide polymer’s characteristics were analyzed. This study will consider a characteristics of synthesizing peptides, which have excellent biocompatibility for high molecular weight from chirality controlled β-amino acid and analyze their structures including helical structure and physical characteristics References 1. G. Q. Xu, L. Gong, Z. Yang and X. Y. Liu, Soft Matter, 2014, 10, 2116. 2. B. M. Mowery, A. M. Lindner, B. Weisblum, S. S. Stahl and S. H. Gellman J. Am. Chem. Soc. 2009, 131, 9735. 3. Zhang, J. H.; Kissounko, D. A.; Lee, S. E.; Gellman, S. H.; Stahl, S. S. J. Am. Chem. Soc. 2009, 131, 1589