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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
BIO.P-262 |
| Subject |
Chemical function of α-synuclein monomers and oligomers on membrane fusion |
| Authors |
Gyeongji Yoo, Nam Ki Lee1,*
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Korea
1Division of Chemistry, Seoul National University, Korea
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| Abstract |
During the initial phase of Parkinson's disease, α-synuclein(α-Syn) monomers and oligomers are mixed in real neurons. Monomeric α-Syn functions as a chaperone protein for SNARE complex formation, and promotes neurotransmitter release. However, large oligomers inhibit vesicle fusion by blocking SNARE complex formation. Interestingly, both bind to the N-terminal of synaptobrevin-2. Using in vitro bulk vesicle fusion assay, we found that α-Syn monomers and oligomers inhibit lipid mixing synergistically. Also, we observed that this effect depends on the interaction of α-Syn with vesicle lipids. Our work can help us understand the role of α-Syn in the pathology of Parkinson's disease.
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| E-mail |
kyungji7@postech.ac.kr |
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121st General Meeting of the KCS