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|
| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-361 |
| Subject |
A development of NIR-emitting probe for imaging of mitochondrial NADH |
| Authors |
Jinhui Joo, Min Hee Lee1,*
Chemistry, Sookmyung Women's University, Korea
1Department of Chemistry, Sookmyung Women's University, Korea
|
| Abstract |
Nicotinamide adenine dinucleotide (NADH) is a coenzyme involving in many redox reactions in living cells. In particular, the NADH plays a crucial role in the production of energy in the mitochondria. In this regard, we developed a NIR fluorescent probe (1) that can image mitochondrial NADH. This probe consists of NIR fluorophore as signaling unit, electron-deficient moiety as a reactive site to NADH, and triphenylphosphonium salt as a mitochondria targeting group. The 1 is almost none-fluorescent, however, upon reacting with NADH a significant fluorescence increase is monitored in both solution and live human cells. |
| E-mail |
wnwlsgml2313@gmail.com |
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121st General Meeting of the KCS