|
Type |
Poster Presentation |
Area |
Life Chemistry |
Room No. |
Event Hall |
Time |
4월 20일 (금요일) 11:00~12:30 |
Code |
BIO.P-295 |
Subject |
Mutation Effect for Control of Peptide-Surface Interaction and Structure |
Authors |
YOUNG HYUN NO, Yong Ho Kim1,* Department of Nano Science and Nanotechnology, Sungkyunkwan University, Korea 1Department of Chemistry, SKKU Advanced Institute o, Sungkyunkwan University, Korea |
Abstract |
Peptide-surface interactions has highlighted increasinglyfor various applications, including platforms for studying biological phenomena at single-molecule level, sensors detecting biomolecules with single-molecule level sensitivity, and means of patterning sub-5-nm inorganic materials at single-particle level. Here, were report the mutation effect for control of peptide-surface interactions to elucidate the difference in surface physical interaction strengths on hydrophobic or hydrophilic surface. We demonstrate hydrophobic interaction by molecular dynamics (MD) simulation to calculate the binding energy and visualize conformational changes of peptides on solid surface. Computational work in molecular dynamics (MD) simulation confirms that the peptides are strongly attracted adhere to hydrophobic surface via hydrophobic interactions Surface assisted laser desorption (SALDI) mass spectrometry measurement correlates with the signal intensity of SALDI mass spectrometry. These findings provide a novel concept to understand peptides associated with solid surfaces. |
E-mail |
shxl114@gmail.com |
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