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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Analytical Chemists I |
| Room No. |
Room 201A |
| Time |
THU 09:30-: |
| Code |
ANAL1.O-3 |
| Subject |
Separation of carrier free 166Ho from 166Dy/166Ho and their application on in vivo generator system |
| Authors |
Bo bae Cho, kang hyuk choi*
Korea Atomic Energy Research Institute, Korea
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| Abstract |
“in vivo ’generator is a concept that the long lived parent radionuclides are delivered to target tissue and then in vivo decay into short-lived daughter radionuclides with high decay energetic beta particles to achieve high-dose targeted radiotherapy. This strategy can help to overcome physical limitation of established radiotherapy which use the nuclides with high decay energies and too short half-lives for targeted systemic therapies.
Moreover, The uses of radiolanthanide can induce cancer cell apoptosis due to their proper LET (Linear Energy Transfer). Among these radiolanthanides, Holmium-166(166Ho) have been utilized in field of medical radiotherapeutic application such as radioimmuno-specific pharmaceuticals, bone marrow ablation and radiation synovectomy owing to its high- β radiation energy [T1/2=26.6 h, Eβmax=1855 keV(51%), Eβav=666 keV]. 166Ho can be produced by (n,γ)β reaction from 166Dy as parent nuclide [T1/2=81.5 h, Eβmax=486.8 keV, EEβav=130 keV] and the 166Dy can be produced by double neutron capture reaction of stable 164Dy.
(n,γ)β reaction: 164Dy(n,γ)165Dy(n, γ)166Dy → 166Ho
In this research, the carrier free166Ho and Dy (164Dy and 166Dy) were separated from 166Dy/166Ho by self-made automatic HPLC system. The separated Dy (164Dy and 166Dy) was soaked into microsphere for in vivo generator system. In this present, we will discuss the separation of 166Dy/166Ho and preparation of microspheres in detail.
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| E-mail |
akslqjso5@hanamail.net |
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121st General Meeting of the KCS